Revised edition of: Kelley and Firestein's textbook of rheumatology / Gary S. Firestein [and others]. Tenth edition, ©2017.

Includes bibliographical references.

Biology of the normal joint -- Synovium -- Cartilage and chondrocytes -- Biology, physiology, and morphology of bone -- Muscle: anatomy, physiology, and biochemistry -- Biomechanics -- Regenerative medicine and tissue engineering -- Proteinases and matrix degradation -- Dendritic cells -- Mononuclear phagocytes -- Neutrophils -- T lymphocytes -- B cells -- Fibroblasts and fibroblast-like synoviocytes -- Mast cells -- Innate lymphoid cells and natural killer cells -- Platelets and megakaryocytes -- Principles of signaling -- The immunologic repercussions of cell death -- Innate immunity -- Adaptive immunity -- Autoimmunity and tolerance -- The microbiome in health and disease -- Metabolic regulation of immunity -- Genetics of rheumatic diseases -- Epigenetics of rheumatic diseases -- Complement system -- Prostaglandins, leukotrienes, and related compounds -- Chemokines and cellular recruitment -- Angiogenesis -- Cytokines -- Experimental models for rheumatoid arthritis -- Neuronal regulation of pain and inflammation -- Clinical research methods in rheumatic disease -- Economic impact of arthritis and rheumatic conditions -- Assessment of health outcomes -- Biomarkers in rheumatology -- Occupational and recreational musculoskeletal disorders -- Cardiovascular risk in inflammatory rheumatic disease -- Cancer risk in rheumatic diseases -- Introduction to physical medicine and rehabilitation -- Pregnancy and rheumatic diseases -- History and physical examination of the musculoskeletal system -- Ultrasound in rheumatology -- Evaluation of monoarticular and polyarticular arthritis -- Skin and rheumatic diseases -- The eye and rheumatic diseases -- Neck pain -- Shoulder pain -- Low back pain -- Hip and knee pain -- Foot and ankle pain -- Hand and wrist pain -- Temporomandibular joint pain -- Fibromyalgia -- Synovial fluid analyses, synovial biopsy, and synovial pathology -- Arthrocentesis and injection of joints and soft tissues -- Anti-nuclear antibodies -- Autoantibodies in rheumatoid arthritis -- Acute phase reactants -- Imaging in rheumatic diseases -- Therapeutic targeting of prostanoids -- Glucocorticoid therapy -- Traditional DMARDs: methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, and combination therapies -- Immunosuppressive drugs -- Anti-cytokine therapies -- Cell-targeted biologics and emerging targets: rituximab, abatacept, and other biologics -- Intra-cellular targeting agents in rheumatic disease -- Urate-lowering therapy -- Bisphosphonates -- Analgesic agents in rheumatic disease -- Nutrition and rheumatic diseases -- Evaluation and management of early undifferentiated arthritis -- Etiology of rheumatoid arthritis -- Pathogenesis of rheumatoid arthritis -- Clinical features of rheumatoid arthritis -- Treatment of rheumatoid arthritis -- Sjögren's syndrome -- Etiology and pathogenesis of spondyloarthritis -- Ankylosing spondylitis and other forms of axial spondyloarthritis -- Reactive arthritis -- Psoriatic arthritis --

Inflammatory bowel disease-associated arthritis and other enteropathic arthropathies -- Etiology and pathogenesis of systemic lupus erythematosus -- Clinical features of systemic lupus erythematosus -- Treatment of systemic lupus erythematosus -- Antiphospholipid syndrome -- Etiology and pathogenesis of systemic sclerosis -- Clinical features and treatment of scleroderma -- Inflammatory diseases of muscle and other myopathies -- Overlap syndromes -- Classification and epidemiology of systemic vasculitis -- Giant cell arteritis, polymyalgia rheumatica, and Takayasu's arteritis -- Anti-neutrophil cytoplasmic antibody-associated vasculitis -- Polyarteritis nodosa and related disorders -- Immune complex-mediated small vessel vasculitis -- Primary angiitis of the central nervous system -- Behçet's disease -- Pathogenesis of inflammasome-mediated diseases -- Etiology and pathogenesis of hyperuricemia and gout -- Clinical features and treatment of gout -- Calcium crystal disease: calcium pyrophosphate dihydrate and basic calcium phosphate -- Familial autoinflammatory syndromes -- Pathogenesis of osteoarthritis -- Clinical features of osteoarthritis -- Treatment of osteoarthritis -- Metabolic bone disease -- Proliferative bone diseases -- Osteonecrosis -- Relapsing polychondritis -- Heritable diseases of connective tissue -- Etiology and pathogenesis of juvenile idiopathic arthritis -- Clinical features and treatment of juvenile idiopathic arthritis -- Childhood-onset systemic lupus erythematosus, drug-induced lupus in children, and neonatal lupus -- Juvenile dermatomyositis, scleroderma, vasculitis, and autoimmune brain disease -- Bacterial arthritis -- Lyme disease -- Mycobacterial infections of bones and joints -- Fungal infections of bones and joints -- Rheumatic manifestations of HIV infection -- Viral arthritis -- Rheumatic fever and post-streptococcal arthritis -- Amyloidosis -- Sarcoidosis -- Hemochromatosis -- Hemophilic arthropathy -- Rheumatic manifestations of hemoglobinopathies -- IgG4-related disease -- Arthritis accompanying endocrine and metabolic disorders -- Rheumatic paraneoplastic syndromes: links between malignancy and autoimmunity -- Tumors and tumor-like lesions of joints and related structures -- Autoimmune complications of immune checkpoint inhibitors for cancer.